Item Type | Name |
Concept
|
beta-Endorphin
|
Concept
|
Humans
|
Concept
|
Receptors, Bombesin
|
Concept
|
Down-Regulation
|
Concept
|
Hot Temperature
|
Concept
|
Pilot Projects
|
Concept
|
Primates
|
Concept
|
Injections, Intradermal
|
Concept
|
Escherichia coli
|
Concept
|
Sweetening Agents
|
Concept
|
Drug Partial Agonism
|
Concept
|
Pain Measurement
|
Concept
|
Macaca mulatta
|
Concept
|
Alfentanil
|
Concept
|
Nicotinic Agonists
|
Concept
|
Substance P
|
Concept
|
Inflammation
|
Concept
|
Heating
|
Concept
|
Cricetinae
|
Concept
|
Blood Glucose
|
Concept
|
Acetylcholine
|
Concept
|
Anesthesia, Local
|
Concept
|
Interleukin-17
|
Concept
|
Morphine Derivatives
|
Concept
|
Receptors, Opioid
|
Concept
|
Diazepam
|
Concept
|
Cell Membrane
|
Concept
|
Crystallography, X-Ray
|
Concept
|
Pain Threshold
|
Concept
|
Hyperalgesia
|
Concept
|
Analysis of Variance
|
Concept
|
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
|
Concept
|
Enzyme Stability
|
Concept
|
Reaction Time
|
Concept
|
Interleukin-1beta
|
Concept
|
Methylphenidate
|
Concept
|
Nerve Growth Factors
|
Concept
|
Toluene 2,4-Diisocyanate
|
Concept
|
Bombesin
|
Concept
|
Clostridium perfringens
|
Concept
|
Diuresis
|
Concept
|
Swimming
|
Concept
|
Alzheimer Disease
|
Concept
|
Spiro Compounds
|
Concept
|
Binding Sites
|
Concept
|
Macaca
|
Concept
|
Phenalenes
|
Concept
|
Dogs
|
Concept
|
Animals
|
Concept
|
Binding, Competitive
|
Concept
|
Computer Simulation
|
Concept
|
Histamine
|
Concept
|
Interleukin-23
|
Concept
|
Neurodegenerative Diseases
|
Concept
|
Molecular Dynamics Simulation
|
Concept
|
Morphinans
|
Concept
|
Butorphanol
|
Concept
|
Receptors, Atrial Natriuretic Factor
|
Concept
|
Cycloheptanes
|
Concept
|
Mice, Knockout
|
Concept
|
Buprenorphine
|
Concept
|
Antibodies
|
Concept
|
Receptors, Cannabinoid
|
Concept
|
Natriuretic Peptide, Brain
|
Concept
|
Benzomorphans
|
Concept
|
Calcium
|
Concept
|
Conditioning, Operant
|
Concept
|
Dermatitis, Allergic Contact
|
Concept
|
STAT3 Transcription Factor
|
Concept
|
TRPV Cation Channels
|
Concept
|
CHO Cells
|
Concept
|
Blotting, Western
|
Concept
|
Analgesics, Opioid
|
Concept
|
Injections, Spinal
|
Concept
|
Cinnamates
|
Concept
|
Opioid Peptides
|
Concept
|
Bradykinin
|
Concept
|
Lipopolysaccharides
|
Concept
|
Injections, Subcutaneous
|
Concept
|
Cricetulus
|
Concept
|
Anti-Inflammatory Agents, Non-Steroidal
|
Concept
|
Hydrocortisone
|
Concept
|
Dynorphins
|
Concept
|
Neurotensin
|
Concept
|
Drug Interactions
|
Concept
|
Anticonvulsants
|
Concept
|
Integrin beta3
|
Concept
|
Area Under Curve
|
Concept
|
Spectrometry, Mass, Electrospray Ionization
|
Concept
|
Mice
|
Concept
|
tau Proteins
|
Concept
|
Excitatory Amino Acid Antagonists
|
Concept
|
Oxycodone
|
Concept
|
Muscle Relaxation
|
Concept
|
Immunoenzyme Techniques
|
Concept
|
Drug Evaluation, Preclinical
|
Concept
|
Thalamus
|
Concept
|
Brain Chemistry
|
Concept
|
Pyrroles
|
Concept
|
Hypersensitivity
|
Concept
|
Molecular Structure
|
Concept
|
Mice, Inbred ICR
|
Concept
|
Food Preferences
|
Concept
|
Naproxen
|
Concept
|
Nerve Fibers, Unmyelinated
|
Concept
|
Cerebral Cortex
|
Concept
|
Seizures
|
Concept
|
Diabetes Mellitus, Type 2
|
Concept
|
Mice, Inbred C57BL
|
Concept
|
Haloperidol
|
Concept
|
Anti-Inflammatory Agents
|
Concept
|
Receptors, Opioid, mu
|
Concept
|
Cells, Cultured
|
Concept
|
Receptors, Nicotinic
|
Concept
|
Microsomes, Liver
|
Concept
|
Fentanyl
|
Concept
|
Injections, Intraperitoneal
|
Concept
|
Dopamine Uptake Inhibitors
|
Concept
|
Guanosine 5'-O-(3-Thiotriphosphate)
|
Concept
|
Drug Synergism
|
Concept
|
Isotope Labeling
|
Concept
|
Signal Transduction
|
Concept
|
Heart Rate
|
Concept
|
Receptors, Neurotensin
|
Concept
|
RNA, Messenger
|
Concept
|
Naltrexone
|
Concept
|
Cytokines
|
Concept
|
Enzyme-Linked Immunosorbent Assay
|
Concept
|
Receptors, AMPA
|
Concept
|
Disease Models, Animal
|
Concept
|
Receptors, Opioid, kappa
|
Concept
|
Injections, Intramuscular
|
Concept
|
Calcium Channels, N-Type
|
Concept
|
Calcium Channel Blockers
|
Concept
|
Narcotics
|
Concept
|
Temperature
|
Concept
|
Muscle Contraction
|
Concept
|
Motor Activity
|
Concept
|
Enkephalin, D-Penicillamine (2,5)-
|
Concept
|
Data Interpretation, Statistical
|
Concept
|
Blood Pressure
|
Concept
|
Morphine
|
Concept
|
Pain
|
Concept
|
Dermatitis, Atopic
|
Concept
|
Stereoisomerism
|
Concept
|
Neuralgia
|
Concept
|
Macaca fascicularis
|
Concept
|
Prolactin
|
Concept
|
Injections, Intraventricular
|
Concept
|
Drug Design
|
Concept
|
Drug Tolerance
|
Concept
|
Tetrahydroisoquinolines
|
Concept
|
Integrin alpha5
|
Concept
|
Receptor, Bradykinin B1
|
Concept
|
Mutagenesis, Site-Directed
|
Concept
|
Ileum
|
Concept
|
Pyrazoles
|
Concept
|
Cell Degranulation
|
Concept
|
Quantum Theory
|
Concept
|
Narcotic Antagonists
|
Concept
|
Polyethylene Glycols
|
Concept
|
Naloxone
|
Concept
|
Sensitivity and Specificity
|
Concept
|
Alcohol Drinking
|
Concept
|
Cell Adhesion Molecules
|
Concept
|
Amitriptyline
|
Concept
|
Cyclopropanes
|
Concept
|
Injections
|
Concept
|
Heroin
|
Concept
|
Toll-Like Receptors
|
Concept
|
Macrophages
|
Concept
|
Antipruritics
|
Concept
|
Chemokine CCL3
|
Concept
|
GTP-Binding Proteins
|
Concept
|
Cisterna Magna
|
Concept
|
Nalbuphine
|
Concept
|
Kallidin
|
Concept
|
Spectrometry, Fluorescence
|
Concept
|
Atmospheric Pressure
|
Concept
|
Guinea Pigs
|
Concept
|
Adrenocorticotropic Hormone
|
Concept
|
Hypothalamo-Hypophyseal System
|
Concept
|
Rats
|
Concept
|
Autoradiography
|
Concept
|
Benzeneacetamides
|
Concept
|
In Situ Hybridization
|
Concept
|
Models, Molecular
|
Concept
|
Benzamides
|
Concept
|
Integrins
|
Concept
|
Analgesics, Non-Narcotic
|
Concept
|
Butyrylcholinesterase
|
Concept
|
Rhodococcus
|
Concept
|
Rats, Wistar
|
Concept
|
Cell Line
|
Concept
|
Analgesics
|
Concept
|
Hydrolysis
|
Concept
|
Clonidine
|
Concept
|
Eating
|
Concept
|
Rats, Sprague-Dawley
|
Concept
|
Carboxylic Ester Hydrolases
|
Concept
|
Central Nervous System Agents
|
Concept
|
Protein Conformation
|
Concept
|
Capsaicin
|
Concept
|
Trypsin
|
Concept
|
Tyrphostins
|
Concept
|
Gas Gangrene
|
Concept
|
Neurokinin B
|
Concept
|
Chemokines
|
Concept
|
Hypothermia
|
Concept
|
Enkephalins
|
Concept
|
Receptors, Opioid, delta
|
Concept
|
Interferon Type I
|
Concept
|
Injections, Intravenous
|
Concept
|
Neurotransmitter Agents
|
Concept
|
Antidepressive Agents
|
Concept
|
Cell Line, Tumor
|
Concept
|
Brain-Derived Neurotrophic Factor
|
Concept
|
Freezing Reaction, Cataleptic
|
Concept
|
Electrocardiography
|
Concept
|
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
|
Concept
|
Atrial Natriuretic Factor
|
Concept
|
Estrogen Receptor alpha
|
Academic Article
|
Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.
|
Academic Article
|
Effects of spinally administered bifunctional nociceptin/orphanin FQ peptide receptor/µ-opioid receptor ligands in mouse models of neuropathic and inflammatory pain.
|
Academic Article
|
Physiological function of gastrin-releasing peptide and neuromedin B receptors in regulating itch scratching behavior in the spinal cord of mice.
|
Academic Article
|
The effects of nociceptin/orphanin FQ receptor agonist Ro 64-6198 and diazepam on antinociception and remifentanil self-administration in rhesus monkeys.
|
Academic Article
|
Cocaine esterase: interactions with cocaine and immune responses in mice.
|
Academic Article
|
Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.
|
Academic Article
|
The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats.
|
Academic Article
|
The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.
|
Academic Article
|
Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.
|
Academic Article
|
Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates.
|
Academic Article
|
Roles of µ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.
|
Academic Article
|
Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.
|
Academic Article
|
Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys.
|
Academic Article
|
Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats.
|
Academic Article
|
The therapeutic potential of nociceptin/orphanin FQ receptor agonists as analgesics without abuse liability.
|
Academic Article
|
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaine.
|
Academic Article
|
Amelioration of the cardiovascular effects of cocaine in rhesus monkeys by a long-acting mutant form of cocaine esterase.
|
Academic Article
|
Effects of a long-acting mutant bacterial cocaine esterase on acute cocaine toxicity in rats.
|
Academic Article
|
Central kappa-opioid receptor-mediated antidepressant-like effects of nor-Binaltorphimine: behavioral and BDNF mRNA expression studies.
|
Academic Article
|
Effects of butorphanol on morphine-induced itch and analgesia in primates.
|
Academic Article
|
Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.
|
Academic Article
|
Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.
|
Academic Article
|
Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
|
Academic Article
|
The spinal antinociceptive effects of endomorphins in rats: behavioral and G protein functional studies.
|
Academic Article
|
Most efficient cocaine hydrolase designed by virtual screening of transition states.
|
Academic Article
|
Electrospray sample deposition for matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI mass spectrometry with attomole detection limits.
|
Academic Article
|
Thermostable variants of cocaine esterase for long-time protection against cocaine toxicity.
|
Academic Article
|
Effects of cocaine esterase following its repeated administration with cocaine in mice.
|
Academic Article
|
PEGylation of bacterial cocaine esterase for protection against protease digestion and immunogenicity.
|
Academic Article
|
Structural analysis of thermostabilizing mutations of cocaine esterase.
|
Academic Article
|
Pharmacokinetic evidence for the long-lasting effect of nor-binaltorphimine, a potent kappa opioid receptor antagonist, in mice.
|
Academic Article
|
Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain.
|
Academic Article
|
[Dmt1]N/OFQ(1-13)-NH2: a potent nociceptin/orphanin FQ and opioid receptor universal agonist.
|
Academic Article
|
Seizure activity involved in the up-regulation of BDNF mRNA expression by activation of central mu opioid receptors.
|
Academic Article
|
Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.
|
Academic Article
|
Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects.
|
Academic Article
|
Differential in vivo potencies of naltrexone and 6beta-naltrexol in the monkey.
|
Academic Article
|
How best to fight that nasty itch - from new insights into the neuroimmunological, neuroendocrine, and neurophysiological bases of pruritus to novel therapeutic approaches.
|
Academic Article
|
Antinociceptive, hypothermic, hypotensive, and reinforcing effects of a novel neurotensin receptor agonist, NT69L, in rhesus monkeys.
|
Academic Article
|
Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.
|
Academic Article
|
The role of central mu opioid receptors in opioid-induced itch in primates.
|
Academic Article
|
Characterization of scratching responses in rats following centrally administered morphine or bombesin.
|
Academic Article
|
Ultra-long antagonism of kappa opioid agonist-induced diuresis by intracisternal nor-binaltorphimine in monkeys.
|
Academic Article
|
Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
|
Academic Article
|
Studies of micro-, kappa-, and delta-opioid receptor density and G protein activation in the cortex and thalamus of monkeys.
|
Academic Article
|
Activation of kappa-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys.
|
Academic Article
|
Relative reinforcing effects of three opioids with different durations of action.
|
Academic Article
|
Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.
|
Academic Article
|
Gangrenous Clostridium perfringens infection and subsequent wound management in a rhesus macaque (Macaca mulatta).
|
Academic Article
|
Comparison of the opioid receptor antagonist properties of naltrexone and 6 beta-naltrexol in morphine-naïve and morphine-dependent mice.
|
Academic Article
|
Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists.
|
Academic Article
|
Effects of the NOP agonist SCH221510 on producing and attenuating reinforcing effects as measured by drug self-administration in rats.
|
Academic Article
|
Neuraxial opioid-induced itch and its pharmacological antagonism.
|
Academic Article
|
Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates.
|
Academic Article
|
TC-2559, an a4ß2 nicotinic acetylcholine receptor agonist, suppresses the expression of CCL3 and IL-1ß through STAT3 inhibition in cultured murine macrophages.
|
Academic Article
|
Central N/OFQ-NOP Receptor System in Pain Modulation.
|
Academic Article
|
Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.
|
Academic Article
|
Spinal antinociceptive effects of the novel NOP receptor agonist PWT2-nociceptin/orphanin FQ in mice and monkeys.
|
Academic Article
|
Supraspinal actions of nociceptin/orphanin FQ, morphine and substance P in regulating pain and itch in non-human primates.
|
Academic Article
|
GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys.
|
Academic Article
|
Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.
|
Academic Article
|
Diltiazem enhances the analgesic but not the respiratory depressant effects of morphine in rhesus monkeys.
|
Academic Article
|
An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception.
|
Academic Article
|
Local administration of mu or kappa opioid agonists attenuates capsaicin-induced thermal hyperalgesia via peripheral opioid receptors in rats.
|
Academic Article
|
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys.
|
Academic Article
|
Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys.
|
Academic Article
|
The effects of the phyllolitorin analogue [desTrp(3), Leu(8)]phyllolitorin on scratching induced by bombesin and related peptides in rats.
|
Academic Article
|
Comparison of Antinociceptive Effects Induced by Kappa Opioid Agonists in Male and Female Mice.
|
Academic Article
|
Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys.
|
Academic Article
|
kappa-Opioid receptor binding populations in rhesus monkey brain: relationship to an assay of thermal antinociception.
|
Academic Article
|
The role of peripheral mu opioid receptors in the modulation of capsaicin-induced thermal nociception in rhesus monkeys.
|
Academic Article
|
A novel orvinol analog, BU08028, as a safe opioid analgesic without abuse liability in primates.
|
Academic Article
|
Altered expression of glial markers, chemokines, and opioid receptors in the spinal cord of type 2 diabetic monkeys.
|
Academic Article
|
Pharmacological studies on the NOP and opioid receptor agonist PWT2-[Dmt1]N/OFQ(1-13).
|
Academic Article
|
Differential mRNA expression of neuroinflammatory modulators in the spinal cord and thalamus of type 2 diabetic monkeys.
|
Academic Article
|
A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates.
|
Academic Article
|
Effects of NOP-Related Ligands in Nonhuman Primates.
|
Academic Article
|
Neuromedin B Induces Acute Itch in Mice via the Activation of Peripheral Sensory Neurons.
|
Academic Article
|
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates.
|
Academic Article
|
Effects of stimulation of mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors on alcohol drinking in rhesus monkeys.
|
Academic Article
|
Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates.
|
Academic Article
|
Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch.
|
Academic Article
|
GRP receptor and AMPA receptor cooperatively regulate itch-responsive neurons in the spinal dorsal horn.
|
Academic Article
|
Therapeutic potentials of NOP and MOP receptor coactivation for the treatment of pain and opioid abuse.
|
Academic Article
|
Antinociceptive, reinforcing, and pruritic effects of the G-protein signalling-biased mu opioid receptor agonist PZM21 in non-human primates.
|
Academic Article
|
STING controls nociception via type I interferon signalling in sensory neurons.
|
Academic Article
|
Pleiotropic Effects of Kappa Opioid Receptor-Related Ligands in Non-human Primates.
|
Academic Article
|
Synthesis of Enantiopure PZM21, A Novel Biased Agonist of the Mu-Opioid Receptor.
|
Academic Article
|
Nociceptin/Orphanin FQ Peptide Receptor-Related Ligands as Novel Analgesics.
|
Academic Article
|
Translational value of non-human primates in opioid research.
|
Academic Article
|
Usefulness of the measurement of neurite outgrowth of primary sensory neurons to study cancer-related painful complications.
|
Academic Article
|
Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine.
|
Academic Article
|
Functional Profile of Systemic and Intrathecal Cebranopadol in Nonhuman Primates.
|
Academic Article
|
Morphine acts on spinal dynorphin neurons to cause itch through disinhibition.
|
Academic Article
|
Functional roles of neuromedin B and gastrin-releasing peptide in regulating itch and pain in the spinal cord of non-human primates.
|
Academic Article
|
Functional consequences of short-term exposure to opioids versus cannabinoids in nonhuman primates.
|
Academic Article
|
Characterization of Early Alzheimer's Disease-Like Pathological Alterations in Non-Human Primates with Aging: A Pilot Study.
|
Academic Article
|
Potential therapeutic targets for the treatment of opioid abuse and pain.
|
Academic Article
|
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.
|
Academic Article
|
Chemogenetic activation of central gastrin-releasing peptide-expressing neurons elicits itch-related scratching behavior in male and female mice.
|
Academic Article
|
[Therapeutic potentials of safe opioid analgesics targeting nociceptin/orphanin FQ peptide receptor].
|
Academic Article
|
Enhanced antidepressant-like effects of a delta opioid receptor agonist, SNC80, in rats under inflammatory pain.
|
Academic Article
|
Nociceptin Receptor-Related Agonists as Safe and Non-addictive Analgesics.
|
Academic Article
|
PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior.
|